About the Company:
The company is an early-stage biotechnology company operating in Stealth mode developing lipid nanoparticle (LNP) technologies for the treatment of lung diseases. Co-founded by leading academic scientists and pharmaceutical industry leaders, we are building a pipeline of nucleic acid-based therapies with the potential to make a meaningful impact on human health. Backed by a Series A fund raise, the company is on track to deliver two clinic-ready assets in 24 months.
Our research laboratory is located at B+Labs in Philadelphia, a growing biotech hub with proximity to world-class academic and industry institutions. We foster a collaborative, science-driven environment and offer opportunities for mentorship and professional growth alongside experienced engineers and scientists.
Position Summary
We are seeking 2 highly motivated Research Associates to support both in vitro and in vivo research activities.
· One research associate will split time between animal work (mice) and laboratory
· One research associate will be laboratory only
Depending on experience and expertise, the successful candidate will contribute to molecular biology, cell culture, nanoparticle characterization, and/or animal studies (mice) supporting the development of nucleic acid therapeutics for lung disease.
This is a hands-on laboratory role requiring strong organizational skills, attention to detail, and the ability to work independently in a fast-paced startup environment.
Candidates with experience in mammalian cell culture, primary airway epithelial cells, and/or mouse handling and dosing techniques are strongly encouraged to apply.
Key Responsibilities
Laboratory Operations
- Perform basic to complex laboratory assays in compliance with Good Laboratory Practices (GLP) and Standard Operating Procedures (SOPs)
- Prepare buffers, media, and reagents
- Calibrate, maintain, and troubleshoot laboratory equipment
- Maintain accurate experimental records in electronic or written laboratory notebooks
- Assist with drafting and revising SOPs, protocols, testing records, and reports
Cell Culture & Molecular Biology
- Maintain mammalian and primary cell cultures, including aseptic handling, expansion, passaging, cryopreservation, and counting
- Perform biomolecular and biochemical assays including:
- qPCR/PCR
- ELISA
- RNA/DNA/protein extraction
- Western blotting
- Fluorescence and absorbance-based assays
- Support nanoparticle characterization studies (e.g., DLS)
In Vivo Research Responsibilities (for candidates with animal experience)
- Perform routine mouse procedures including:
- Tail vein, retro-orbital, and intraperitoneal injections
- Anesthesia and monitoring
- Blood collection and tissue harvests
- Accurately document animal procedures and related data
- Support tissue processing for downstream analyses such as flow cytometry or histology
- Assist with in vivo imaging studies (IVIS), when applicable
Collaboration & Scientific Rigor
- Analyze and communicate experimental results with accuracy and scientific rigor
- Communicate effectively with supervisors and colleagues regarding daily laboratory activities
- Work independently with minimal supervision while contributing to team objectives
- Maintain high standards of laboratory safety and organization
Qualifications
Required
- Bachelor’s degree in Biology, Biochemistry, Biomedical Sciences, or a related scientific discipline
- Hands-on laboratory experience in molecular biology and cell culture
- Strong organizational skills and attention to detail
- Excellent written and verbal communication skills
- Ability to follow protocols and work effectively in a collaborative team environment
Preferred
- Experience with mammalian or primary cell culture
- Experience with Normal Human Bronchial Epithelial (NHBE) cells
- Experience with mouse handling and dosing procedures
- Experience working in a vivarium or BSL-2 environment
- Familiarity with nanoparticle systems and characterization techniques (e.g., DLS)
- Experience with IVIS imaging, flow cytometry, or histological tissue processing
- Experience working in GLP-regulated environments
Working Conditions
- Work is primarily conducted in BSL-2 laboratory and/or vivarium environments
- May involve handling human and animal-derived materials
- Occasional flexibility for weekend or off-hours work may be required to support experiments and cell culture maintenance
Compensation & Benefits
Competitive compensation and benefits package offered, including:
- Medical, dental, and vision insurance
- 401(k)
- Paid time off
- Opportunities for professional growth in a dynamic biotech startup environment
Equal Opportunity Employer
We are committed to building a diverse and inclusive workforce. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, disability, veteran status, gender identity, sexual orientation, genetic information, or any other protected status under applicable laws and regulations.
How to Apply
Apply confidentially by sending your resume/CV to:
team@fatballtx.com
