About the Company:

The company is an early-stage biotechnology company operating in Stealth mode developing lipid nanoparticle (LNP) technologies for the treatment of lung diseases. Co-founded by leading academic scientists and pharmaceutical industry leaders, we are building a pipeline of nucleic acid-based therapies with the potential to make a meaningful impact on human health. Backed by a Series A fund raise, the company is on track to deliver two clinic-ready assets in 24 months.

Our research laboratory is located at B+Labs in Philadelphia, a growing biotech hub with proximity to world-class academic and industry institutions. We foster a collaborative, science-driven environment and offer opportunities for mentorship and professional growth alongside experienced engineers and scientists.

Position Summary

We are seeking 2 highly motivated Research Associates to support both in vitro and in vivo research activities.

· One research associate will split time between animal work (mice) and laboratory

· One research associate will be laboratory only

Depending on experience and expertise, the successful candidate will contribute to molecular biology, cell culture, nanoparticle characterization, and/or animal studies (mice) supporting the development of nucleic acid therapeutics for lung disease.

This is a hands-on laboratory role requiring strong organizational skills, attention to detail, and the ability to work independently in a fast-paced startup environment.

Candidates with experience in mammalian cell culture, primary airway epithelial cells, and/or mouse handling and dosing techniques are strongly encouraged to apply.

Key Responsibilities

Laboratory Operations

Perform basic to complex laboratory assays in compliance with Good Laboratory Practices (GLP) and Standard Operating Procedures (SOPs)
Prepare buffers, media, and reagents
Calibrate, maintain, and troubleshoot laboratory equipment
Maintain accurate experimental records in electronic or written laboratory notebooks
Assist with drafting and revising SOPs, protocols, testing records, and reports

Cell Culture & Molecular Biology

Maintain mammalian and primary cell cultures, including aseptic handling, expansion, passaging, cryopreservation, and counting
Perform biomolecular and biochemical assays including:
qPCR/PCR
ELISA
RNA/DNA/protein extraction
Western blotting
Fluorescence and absorbance-based assays
Support nanoparticle characterization studies (e.g., DLS)

In Vivo Research Responsibilities (for candidates with animal experience)

Perform routine mouse procedures including:
Tail vein, retro-orbital, and intraperitoneal injections
Anesthesia and monitoring
Blood collection and tissue harvests
Accurately document animal procedures and related data
Support tissue processing for downstream analyses such as flow cytometry or histology
Assist with in vivo imaging studies (IVIS), when applicable

Collaboration & Scientific Rigor

Analyze and communicate experimental results with accuracy and scientific rigor
Communicate effectively with supervisors and colleagues regarding daily laboratory activities
Work independently with minimal supervision while contributing to team objectives
Maintain high standards of laboratory safety and organization

Qualifications

Required

Bachelor’s degree in Biology, Biochemistry, Biomedical Sciences, or a related scientific discipline
Hands-on laboratory experience in molecular biology and cell culture
Strong organizational skills and attention to detail
Excellent written and verbal communication skills
Ability to follow protocols and work effectively in a collaborative team environment

Preferred

Experience with mammalian or primary cell culture
Experience with Normal Human Bronchial Epithelial (NHBE) cells
Experience with mouse handling and dosing procedures
Experience working in a vivarium or BSL-2 environment
Familiarity with nanoparticle systems and characterization techniques (e.g., DLS)
Experience with IVIS imaging, flow cytometry, or histological tissue processing
Experience working in GLP-regulated environments

Working Conditions

Work is primarily conducted in BSL-2 laboratory and/or vivarium environments
May involve handling human and animal-derived materials
Occasional flexibility for weekend or off-hours work may be required to support experiments and cell culture maintenance

Compensation & Benefits

Competitive compensation and benefits package offered, including:

Medical, dental, and vision insurance
401(k)
Paid time off
Opportunities for professional growth in a dynamic biotech startup environment

Equal Opportunity Employer

We are committed to building a diverse and inclusive workforce. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, disability, veteran status, gender identity, sexual orientation, genetic information, or any other protected status under applicable laws and regulations.

How to Apply

Apply confidentially by sending your resume/CV to:

team@fatballtx.com

Stealth Mode LNP Company

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Research Associate